A Three Stage Integrative Pathway Search (TIPS) framework to identify toxicity relevant genes and pathways.

ABSTRACT:

Background

The ability to obtain profiles of gene expressions, proteins and metabolites with the advent of high throughput technologies has advanced the study of pathway and network reconstruction. Genome-wide network reconstruction requires either interaction measurements or large amount of perturbation data, often not available for mammalian cell systems. To overcome these shortcomings, we developed a Three Stage Integrative Pathway Search (TIPS(c)) approach to reconstruct context-specific active pathways involved in conferring a specific phenotype, from limited amount of perturbation data. The approach was tested on human liver cells to identify pathways that confer cytotoxicity.

Results

This paper presents a systems approach that integrates gene expression and cytotoxici

SUBMITTER: Li Z 

PROVIDER: S-EPMC1906836 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature