Neuronal conduction of excitation without action potentials based on ceramide production.

ABSTRACT:

Background

Action potentials are the classic mechanism by which neurons convey a state of excitation throughout their length, leading, after synaptic transmission, to the activation of other neurons and consequently to network functioning. Using an in vitro integrated model, we found previously that peripheral networks in the autonomic nervous system can organise an unconventional regulatory reflex of the digestive tract motility without action potentials.

Methodology/principal findings

In this report, we used combined neuropharmacological and biochemical approaches to elucidate some steps of the mechanism that conveys excitation along the nerves fibres without action potentials. This mechanism requires the production of ceramide in membrane lipid rafts, which triggers in th

SUBMITTER: Fasano C 

PROVIDER: S-EPMC1906860 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature