Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse.

ABSTRACT: CNS-focused cDNA microarrays were used to examine gene expression profiles in dorsolateral prefrontal cortex (dlPFC, Area 46) from seven individual sets of age- and post-mortem interval-matched male cocaine abusers and controls. The presence of cocaine and related metabolites was confirmed by gas chromatography-mass spectrometry. Sixty-five transcripts were differentially expressed, indicating alterations in energy metabolism, mitochondria and oligodendrocyte function, cytoskeleton and related signaling, and neuronal plasticity. There was evidence for two distinct states of transcriptional regulation, with increases in gene expression predominating in subjects testing positive for a metabolite indicative of recent 'crack' cocaine abuse and decreased expression profiles in the remaining coc

SUBMITTER: Lehrmann E 

PROVIDER: S-EPMC1907635 | biostudies-literature | 2003

REPOSITORIES: biostudies-literature