Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus.

ABSTRACT: Several lines of evidence have established strong links between transcriptional activity and specific post-translation modifications of histones. Here we show using RNA FISH that in erythroid cells, intergenic transcription in the human beta-globin locus occurs over a region of greater than 250 kb including several genes in the nearby olfactory receptor gene cluster. This entire region is transcribed during S phase of the cell cycle. However, within this region there are approximately 20 kb sub-domains of high intergenic transcription that occurs outside of S phase. These sub-domains are developmentally regulated and enriched with high levels of active modifications primarily to histone H3. The sub-domains correspond to the beta-globin locus control region, which is active at all developme

SUBMITTER: Miles J 

PROVIDER: S-EPMC1910613 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature