Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini.

ABSTRACT:

Background

Cholangiocarcinoma (CCA)--cancer of the bile ducts--is associated with chronic infection with the liver fluke, Opisthorchis viverrini. Despite being the only eukaryote that is designated as a 'class I carcinogen' by the International Agency for Research on Cancer, little is known about its genome.

Results

Approximately 5,000 randomly selected cDNAs from the adult stage of O. viverrini were characterized and accounted for 1,932 contigs, representing ~14% of the entire transcriptome, and, presently, the largest sequence dataset for any species of liver fluke. Twenty percent of contigs were assigned GO classifications. Abundantly represented protein families included those involved in physiological functions that are essential to parasitism, such as anaerobic respira

SUBMITTER: Laha T 

PROVIDER: S-EPMC1913519 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature