The Entamoeba histolytica genome: primary structure and expression of proteolytic enzymes.

ABSTRACT:

Background

A number of studies have shown that peptidases and in particular cysteine peptidases constitute major pathogenicity factors in Entamoeba histolytica. Recent studies have suggested that a considerable number of genes coding for proteolytic enzymes are present within the E. histolytica genome and questions remain about the mode of expression of the various molecules.

Results

By homology search within the recently published amoeba genome, we identified a total of 86 E. histolytica genes coding for putative peptidases, including 46 recently described peptidase genes. In total these comprise (i) 50 cysteine peptidases of different families but most of which belong to the C1 papain superfamily, (ii) 22 different metallo peptidases from at least 11 different families, (i

SUBMITTER: Tillack M 

PROVIDER: S-EPMC1913524 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature