Chemotactic action of prostaglandin E2 on mouse mast cells acting via the PGE2 receptor 3.

ABSTRACT: Mast cells are long-lived cells that are principally recognized for their effector function in helminth infections and allergic reactions. These cells are derived from pluripotential hematopoietic stem cells in the bone marrow that give rise to committed mast cell progenitors in the blood and are recruited to tissues, where they mature. Little is known about the chemotactic signals responsible for recruitment of progenitors and localization of mature mast cells. A mouse model was set up to identify possible mast cell progenitor chemoattractants produced during repeated allergen challenge in vivo. After the final challenge, the nasal mucosa was removed to produce conditioned medium, which was tested in chemotaxis assays against 2-wk murine bone marrow-derived c-kit+ mast cells (BMMC). A sin

SUBMITTER: Weller CL 

PROVIDER: S-EPMC1913869 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature