Carlow virus, a 2002 GII.4 variant Norovirus strain from Ireland.

ABSTRACT:

Background

Noroviruses are the leading cause of infectious non-bacterial gastroenteritis in Ireland (population 4 million). Due to the number of outbreaks, its massive impact on the Irish health service and its seasonality, Norovirus has gained public notoriety as The Winter Vomiting Bug. The increase in cases in Ireland in the 2002-2003 season coincided with the emergence of two new Genogroup II genotype 4 variant clusters of Norovirus worldwide.

Results

Little research has been done on the epidemiology or molecular biology of Norovirus strains in Ireland. In an effort to combat this discrepancy, we cloned a full length human norovirus genome as a cDNA clone (J3) which can produce full length transcripts in vitro. A polymerase mutant cDNA clone (X1), in addition to a sub ge

SUBMITTER: Kearney K 

PROVIDER: S-EPMC1913912 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature