New criteria for selecting the origin of DNA replication in Wolbachia and closely related bacteria.

ABSTRACT:

Background

The annotated genomes of two closely related strains of the intracellular bacterium Wolbachia pipientis have been reported without the identifications of the putative origin of replication (ori). Identifying the ori of these bacteria and related alpha-Proteobacteria as well as their patterns of sequence evolution will aid studies of cell replication and cell density, as well as the potential genetic manipulation of these widespread intracellular bacteria.

Results

Using features that have been previously experimentally verified in the alpha-Proteobacterium Caulobacter crescentus, the origin of DNA replication (ori) regions were identified in silico for Wolbachia strains and eleven other related bacteria belonging to Ehrlichia, Anaplasma, and Rickettsia genera. Thes

SUBMITTER: Ioannidis P 

PROVIDER: S-EPMC1914354 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature