A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers.

ABSTRACT:

Background

The development of resistance to hormone therapy in both breast and prostate cancers is attributed to tens of thousands of patient deaths every year.

Results

From analyses of global gene expression profile data, a nonrandom amount of overlap was observed between the set of genes associated with estrogen receptor negative (ER-), hormone independent breast cancer and the set of genes associated with androgen independent (AI) prostate cancer. A set of 81 genes was identified that were differentially expressed between ER- and ER+ clinical breast tumors and breast cancer cell lines and that showed concordant expression in AI versus AS (androgen sensitive) prostate cell lines. This common gene signature of hormone independence was used to identify a subset of clinically

SUBMITTER: Creighton CJ 

PROVIDER: S-EPMC1914359 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature