Comparison of C. elegans and C. briggsae genome sequences reveals extensive conservation of chromosome organization and synteny.

ABSTRACT: To determine whether the distinctive features of Caenorhabditis elegans chromosomal organization are shared with the C. briggsae genome, we constructed a single nucleotide polymorphism-based genetic map to order and orient the whole genome shotgun assembly along the six C. briggsae chromosomes. Although these species are of the same genus, their most recent common ancestor existed 80-110 million years ago, and thus they are more evolutionarily distant than, for example, human and mouse. We found that, like C. elegans chromosomes, C. briggsae chromosomes exhibit high levels of recombination on the arms along with higher repeat density, a higher fraction of intronic sequence, and a lower fraction of exonic sequence compared with chromosome centers. Despite extensive intrachromosomal rearrang

SUBMITTER: Hillier LW 

PROVIDER: S-EPMC1914384 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature