Unknown

Dataset Information

0

Genetic mapping of hereditary mixed polyposis syndrome to chromosome 6q.

ABSTRACT: Hereditary mixed polyposis syndrome (HMPS) is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas. HMPS appears to be inherited in an autosomal dominant manner. Genetic linkage analysis has been performed on a large family with HMPS. Data did not support linkage to the APC locus or to any of the loci for hereditary nonpolyposis colorectal cancer. Evidence that the HMPS locus lies on chromosome 6q was, however, provided by significant two-point LOD scores for linkage between HMPS and the D6S283 locus. Analysis of recombinants and multipoint linkage analysis suggested that the HMPS locus lies in a 4-cM interval containing the D6S283 locus and flanked by markers D6S468 and D6S301.

SUBMITTER: Thomas HJ 

PROVIDER: S-EPMC1914675 | biostudies-literature | 1996 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Genetic mapping of hereditary mixed polyposis syndrome to chromosome 6q.

Thomas H J HJ   Whitelaw S C SC   Cottrell S E SE   Murday V A VA   Tomlinson I P IP   Markie D D   Jones T T   Bishop D T DT   Hodgson S V SV   Sheer D D   Northover J M JM   Talbot I C IC   Solomon E E   Bodmer W F WF  

American journal of human genetics 19960401 4

Hereditary mixed polyposis syndrome (HMPS) is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas. HMPS appears to be inherited in an autosomal dominant manner. Genetic linkage analysis has been performed on a large family with HMPS. Data did not support linkage to the APC locus or to any of the loci for hereditary nonpolyposis colorectal cancer. Evidence that the HMPS locus lies on chromosome 6q was, however, provided by significant two-point LOD scores for li  ...[more]

Similar Datasets

Unknown Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function.
| S-EPMC2563243 | biostudies-literature
Unknown A novel germline BMPR1A variant (c.72_73delGA) in a Japanese family with hereditary mixed polyposis syndrome.
| S-EPMC7345204 | biostudies-literature
Unknown Fordyce granules and hereditary non-polyposis colorectal cancer syndrome.
| S-EPMC1774669 | biostudies-other
Unknown An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome.
| S-EPMC1180277 | biostudies-literature
Unknown Genomic rearrangements of hMSH6 contribute to the genetic predisposition in suspected hereditary non-polyposis colorectal cancer syndrome.
| S-EPMC1735570 | biostudies-other
Unknown Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs.
| S-EPMC18172 | biostudies-literature
Unknown Novel cleft susceptibility genes in chromosome 6q.
| S-EPMC2924960 | biostudies-literature
Unknown Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q.
| S-EPMC151378 | biostudies-literature
Unknown Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.
| S-EPMC4594751 | biostudies-literature
Unknown Genetic mapping using microcell-mediated chromosome transfer suggests a locus for Nijmegen breakage syndrome at chromosome 8q21-24.
| S-EPMC1716114 | biostudies-other