Meta-regression analysis of high-frequency ventilation vs conventional ventilation in infant respiratory distress syndrome.

ABSTRACT:

Objective

There is considerable heterogeneity among randomized trials comparing high-frequency ventilation (HFV) with conventional mechanical ventilation (CMV) in premature neonates with respiratory distress syndrome. We investigated what factors explained differences in outcome among these trials.

Design

Meta-regression analysis of 15 randomized trials.

Measurements and results

Variables were extracted to explain heterogeneity: year of publication; use of Sensormedics 3100A ventilator for HFV; time on CMV prior to start of study; gestational age; use of surfactant; high lung volume strategy in HFV; and lung protective ventilation strategy in CMV and baseline risk. Chronic lung disease (CLD) and death or CLD were outcome measures. Relative risk ratios were calculated

SUBMITTER: Bollen CW 

PROVIDER: S-EPMC1915647 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature