The cis-regulatory logic of the mammalian photoreceptor transcriptional network.

ABSTRACT: The photoreceptor cells of the retina are subject to a greater number of genetic diseases than any other cell type in the human body. The majority of more than 120 cloned human blindness genes are highly expressed in photoreceptors. In order to establish an integrative framework in which to understand these diseases, we have undertaken an experimental and computational analysis of the network controlled by the mammalian photoreceptor transcription factors, Crx, Nrl, and Nr2e3. Using microarray and in situ hybridization datasets we have produced a model of this network which contains over 600 genes, including numerous retinal disease loci as well as previously uncharacterized photoreceptor transcription factors. To elucidate the connectivity of this network, we devised a computational algor

SUBMITTER: Hsiau TH 

PROVIDER: S-EPMC1916400 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature