Comprehensive analysis of co-occurring domain sets in yeast proteins.

ABSTRACT:

Background

Protein domains are fundamental evolutionary units of protein architecture, composing proteins in a modular manner. Combinations of two or more, possibly non-adjacent, domains are thought to play specific functional roles within proteins. Indeed, while the number of potential co-occurring domain sets (CDSs) is very large, only a few of these occur in nature. Here we study the principles governing domain content of proteins, using yeast as a model species.

Results

We design a novel representation of proteins and their constituent domains as a protein-domain network. An analysis of this network reveals 99 CDSs that occur in proteins more than expected by chance. The identified CDSs are shown to preferentially include ancient domains that are conserved from bacteria

SUBMITTER: Cohen-Gihon I 

PROVIDER: S-EPMC1919370 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature