Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease.

ABSTRACT: Neurodegenerative diseases associated with abnormal protein folding and ordered aggregation require an initial trigger which may be infectious, inherited, post-inflammatory or idiopathic. Proteolytic cleavage to generate vulnerable precursors, such as amyloid-beta peptide (Abeta) production via beta and gamma secretases in Alzheimer's Disease (AD), is one such trigger, but the proteolytic removal of these fragments is also aetiologically important. The levels of Abeta in the central nervous system are regulated by several catabolic proteases, including insulysin (IDE) and neprilysin (NEP). The known association of human acetylcholinesterase (hAChE) with pathological aggregates in AD together with its ability to increase Abeta fibrilization prompted us to search for proteolytic triggers tha

SUBMITTER: Jean L 

PROVIDER: S-EPMC1920558 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature