Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts.

ABSTRACT: Nanostructured biomaterials have tremendous potential for tissue engineering. However, the performance and integration of the nanomaterials in vivo are not well understood. A challenge in vascular tissue engineering is to develop optimal scaffolds and establish expandable cell sources for the construction of tissue-engineered vascular grafts that are nonthrombogenic and have long-term patency. Here, we used tissue-engineered vascular grafts as a model to demonstrate the potential of combining nanofibrous scaffolds and bone marrow mesenchymal stem cells (MSCs) for vascular tissue engineering. Biodegradable nanofibrous scaffolds with aligned nanofibers were used to mimic native collagen fibrils to guide cell organization in vascular grafts. The results from artery bypass experiments showed t

SUBMITTER: Hashi CK 

PROVIDER: S-EPMC1924591 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature