Genetic support for a quantitative trait nucleotide in the ABCG2 gene affecting milk composition of dairy cattle.

ABSTRACT:

Background

Our group has previously identified a quantitative trait locus (QTL) affecting fat and protein percentages on bovine chromosome 6, and refined the QTL position to a 420-kb interval containing six genes. Studies performed in other cattle populations have proposed polymorphisms in two different genes (ABCG2 and OPN) as the underlying functional QTL nucleotide. Due to these conflicting results, we have included these QTNs, together with a large collection of new SNPs produced from PCR sequencing, in a dense marker map spanning the QTL region, and reanalyzed the data using a combined linkage and linkage disequilibrium approach.

Results

Our results clearly exclude the OPN SNP (OPN_3907) as causal site for the QTL. Among 91 SNPs included in the study, the ABCG2 SNP (ABC

SUBMITTER: Olsen HG 

PROVIDER: S-EPMC1924865 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature