Natively unstructured loops differ from other loops.

ABSTRACT: Natively unstructured or disordered protein regions may increase the functional complexity of an organism; they are particularly abundant in eukaryotes and often evade structure determination. Many computational methods predict unstructured regions by training on outliers in otherwise well-ordered structures. Here, we introduce an approach that uses a neural network in a very different and novel way. We hypothesize that very long contiguous segments with nonregular secondary structure (NORS regions) differ significantly from regular, well-structured loops, and that a method detecting such features could predict natively unstructured regions. Training our new method, NORSnet, on predicted information rather than on experimental data yielded three major advantages: it removed the overlap bet

SUBMITTER: Schlessinger A 

PROVIDER: S-EPMC1924875 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature