Functional Associations by Response Overlap (FARO), a functional genomics approach matching gene expression phenotypes.

ABSTRACT: The systematic comparison of transcriptional responses of organisms is a powerful tool in functional genomics. For example, mutants may be characterized by comparing their transcript profiles to those obtained in other experiments querying the effects on gene expression of many experimental factors including treatments, mutations and pathogen infections. Similarly, drugs may be discovered by the relationship between the transcript profiles effectuated or impacted by a candidate drug and by the target disease. The integration of such data enables systems biology to predict the interplay between experimental factors affecting a biological system. Unfortunately, direct comparisons of gene expression profiles obtained in independent, publicly available microarray experiments are typically comp

SUBMITTER: Nielsen HB 

PROVIDER: S-EPMC1924877 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature