The entire organization of transcription units on the Bacillus subtilis genome.

ABSTRACT:

Background

In the post-genomic era, comprehension of cellular processes and systems requires global and non-targeted approaches to handle vast amounts of biological information.

Results

The present study predicts transcription units (TUs) in Bacillus subtilis, based on an integrated approach involving DNA sequence and transcriptome analyses. First, co-expressed gene clusters are predicted by calculating the Pearson correlation coefficients of adjacent genes for all the genes in a series that are transcribed in the same direction with no intervening gene transcribed in the opposite direction. Transcription factor (TF) binding sites are then predicted by detecting statistically significant TF binding sequences on the genome using a position weight matrix. This matrix is a conv

SUBMITTER: Kobayashi H 

PROVIDER: S-EPMC1925097 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature