Association of diminished expression of RASSF1A with promoter methylation in primary gastric cancer from patients of central China.

ABSTRACT:

Background

Although methylation-mediated inactivation of expression of RASSF1A, a candidate tumor suppressor gene, has been observed in several human cancers, the data concerning alteration of RASSF1A expression and methylation in Chinese primary gastric cancer are scarce. Moreover, direct evidence showing the association between protein expression of RASSF1A and primary human cancers is lacking. The aim of this study was to investigate RASSF1A expression in tissue of primary gastric cancer (GC) at mRNA and protein levels, and to establish the possible relationship between DNA methylation status and protein expression of RASSF1A in Chinese.

Methods

Fifty-four patients with primary gastric cancers were included in the study of RASSF1A mRNA expression and methylation status be

SUBMITTER: Ye M 

PROVIDER: S-EPMC1925110 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature