Evidence for systems-level molecular mechanisms of tumorigenesis.

ABSTRACT:

Background

Cancer arises from the consecutive acquisition of genetic alterations. Increasing evidence suggests that as a consequence of these alterations, molecular interactions are reprogrammed in the context of highly connected and regulated cellular networks. Coordinated reprogramming would allow the cell to acquire the capabilities for malignant growth.

Results

Here, we determine the coordinated function of cancer gene products (i.e., proteins encoded by differentially expressed genes in tumors relative to healthy tissue counterparts, hereafter referred to as "CGPs") defined as their topological properties and organization in the interactome network. We show that CGPs are central to information exchange and propagation and that they are specifically organized to promote

SUBMITTER: Hernandez P 

PROVIDER: S-EPMC1929080 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature