TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer.

ABSTRACT:

Introduction

Gene expression profiling of breast carcinomas has increased our understanding of the heterogeneous biology of this disease and promises to impact clinical care. The aim of this study was to evaluate the prognostic value of gene expression-based classification along with established prognostic markers and mutation status of the TP53 gene (tumour protein p53) in a group of breast cancer patients with long-term (12 to 16 years) follow-up.

Methods

The clinical and histopathological parameters of 200 breast cancer patients were studied for their effects on clinical outcome using univariate/multivariate Cox regression. The prognostic impact of mutations in the TP53 gene, identified using temporal temperature gradient gel electrophoresis and sequencing, was also evalu

SUBMITTER: Langerod A 

PROVIDER: S-EPMC1929092 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature