Low E2F1 transcript levels are a strong determinant of favorable breast cancer outcome.

ABSTRACT:

Introduction

We investigated whether mRNA levels of E2F1, a key transcription factor involved in proliferation, differentiation and apoptosis, could be used as a surrogate marker for the determination of breast cancer outcome.

Methods

E2F1 and other proliferation markers were measured by quantitative RT-PCR in 317 primary breast cancer patients from the Stiftung Tumorbank Basel. Correlations to one another as well as to the estrogen receptor and ERBB2 status and clinical outcome were investigated. Results were validated and further compared with expression-based prognostic profiles using The Netherlands Cancer Institute microarray data set reported by Fan and colleagues.

Results

E2F1 mRNA expression levels correlated strongly with the expression of other proliferation

SUBMITTER: Vuaroqueaux V 

PROVIDER: S-EPMC1929097 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature