Unequal evolutionary conservation of human protein interactions in interologous networks.

ABSTRACT:

Background

Protein-protein interaction (PPI) networks have been transferred between organisms using interologs, allowing model organisms to supplement the interactomes of higher eukaryotes. However, the conservation of various network components has not been fully explored. Unequal conservation of certain network components may limit the ability to fully expand the target interactomes using interologs.

Results

In this study, we transfer high quality human interactions to lower eukaryotes, and examine the evolutionary conservation of individual network components. When human proteins are mapped to yeast, we find a strong positive correlation (r = 0.50, P = 3.9 x 10(-4)) between evolutionary conservation and the number of interacting proteins, which is also found when mapped t

SUBMITTER: Brown KR 

PROVIDER: S-EPMC1929159 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature