Modular organization in the reductive evolution of protein-protein interaction networks.

ABSTRACT:

Background

The variation in the sizes of the genomes of distinct life forms remains somewhat puzzling. The organization of proteins into domains and the different mechanisms that regulate gene expression are two factors that potentially increase the capacity of genomes to create more complex systems. High-throughput protein interaction data now make it possible to examine the additional complexity generated by the way that protein interactions are organized.

Results

We have studied the reduction in genome size of Buchnera compared to its close relative Escherichia coli. In this well defined evolutionary scenario, we found that among all the properties of the protein interaction networks, it is the organization of networks into modules that seems to be directly related to the

SUBMITTER: Tamames J 

PROVIDER: S-EPMC1929161 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature