Altered T-cell function in schizophrenia: a cellular model to investigate molecular disease mechanisms.

ABSTRACT: Despite decades of research into the aetiology and pathophysiology of schizophrenia, our understanding of this devastating disorder remains incomplete, with adverse consequences for both diagnosis and treatment. Here we investigate whether differences between patients and controls can be observed in peripheral patient tissue, with a view of establishing a means for dynamic investigations into cell function. In vitro stimulation of peripheral blood CD3+ pan T cells with anti-CD3 (clone OKT3) was used to investigate disease-associated cell responses. T cells from both medicated (n = 39), unmedicated (n = 6) and minimally medicated (n = 5) schizophrenia patients were found to have significantly lower proliferative responses to stimulation, compared to well-matched controls (n = 32). Expressio

SUBMITTER: Craddock RM 

PROVIDER: S-EPMC1930154 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature