Analysis of septins across kingdoms reveals orthology and new motifs.

ABSTRACT:

Background

Septins are cytoskeletal GTPase proteins first discovered in the fungus Saccharomyces cerevisiae where they organize the septum and link nuclear division with cell division. More recently septins have been found in animals where they are important in processes ranging from actin and microtubule organization to embryonic patterning and where defects in septins have been implicated in human disease. Previous studies suggested that many animal septins fell into independent evolutionary groups, confounding cross-kingdom comparison.

Results

In the current work, we identified 162 septins from fungi, microsporidia and animals and analyzed their phylogenetic relationships. There was support for five groups of septins with orthology between kingdoms. Group 1 (which include

SUBMITTER: Pan F 

PROVIDER: S-EPMC1931588 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature