Genomic and phenotypic diversity of coastal Vibrio cholerae strains is linked to environmental factors.

ABSTRACT: Studies of Vibrio cholerae diversity have focused primarily on pathogenic isolates of the O1 and O139 serotypes. However, autochthonous environmental isolates of this species routinely display more extensive genetic diversity than the primarily clonal pathogenic strains. In this study, genomic and metabolic profiles of 41 non-O1/O139 environmental isolates from central California coastal waters and four clinical strains are used to characterize the core genome and metabolome of V. cholerae. Comparative genome hybridization using microarrays constructed from the fully sequenced V. cholerae O1 El Tor N16961 genome identified 2,787 core genes that approximated the projected species core genome within 1.6%. Core genes are almost universally present in strains with widely different niches, sugg

SUBMITTER: Keymer DP 

PROVIDER: S-EPMC1932678 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature