RTX toxin actin cross-linking activity in clinical and environmental isolates of Vibrio cholerae.

ABSTRACT: Vibrio cholerae strains from diverse O-antigen groups were evaluated for RTX toxin actin cross-linking activity. This study demonstrates that the actin cross-linking domain sequence is present within rtxA in the majority of clinical and environmental isolates tested, and the RTX toxin produced by these strains catalyzes the covalent cross-linking of cellular actin.

SUBMITTER: Cordero CL 

PROVIDER: S-EPMC1932970 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature