Update of the G2D tool for prioritization of gene candidates to inherited diseases.

ABSTRACT: G2D (genes to diseases) is a web resource for prioritizing genes as candidates for inherited diseases. It uses three algorithms based on different prioritization strategies. The input to the server is the genomic region where the user is looking for the disease-causing mutation, plus an additional piece of information depending on the algorithm used. This information can either be the disease phenotype (described as an online Mendelian inheritance in man (OMIM) identifier), one or several genes known or suspected to be associated with the disease (defined by their Entrez Gene identifiers), or a second genomic region that has been linked as well to the disease. In the latter case, the tool uses known or predicted interactions between genes in the two regions extracted from the STRING databa

SUBMITTER: Perez-Iratxeta C 

PROVIDER: S-EPMC1933178 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature