FRalanyzer: a tool for functional analysis of fold-recognition sequence-structure alignments.

ABSTRACT: We describe FRalanyzer (Fold Recognition alignment analyzer), a new web tool to visually inspect sequence-structure alignments in order to predict functionally important residues in a query sequence of unknown function. This tool is aimed at helping to infer functional relationships between a query sequence and a template structure, and is particularly useful in analyzing fold recognition (FR) results. Because similar folds do not necessarily share the same function, it is not always straightforward to infer a function from an FR result alone. Manual inspection of the FR sequence-structure alignment is often required in order to search for conservation of functionally important residues. FRalanyzer automates parts of this time-consuming process. FRalanyzer takes as input a sequence-structu

SUBMITTER: Saini HK 

PROVIDER: S-EPMC1933221 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature