GeneHub-GEPIS: digital expression profiling for normal and cancer tissues based on an integrated gene database.

ABSTRACT: GeneHub-GEPIS is a web application that performs digital expression analysis in human and mouse tissues based on an integrated gene database. Using aggregated expressed sequence tag (EST) library information and EST counts, the application calculates the normalized gene expression levels across a large panel of normal and tumor tissues, thus providing rapid expression profiling for a given gene. The backend GeneHub component of the application contains pre-defined gene structures derived from mRNA transcript sequences from major databases and includes extensive cross references for commonly used gene identifiers. ESTs are then linked to genes based on their precise genomic locations as determined by GMAP. This genome-based approach reduces incorrect matches between ESTs and genes, thus min

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC1933245 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature