In vitro human keratinocyte migration rates are associated with SNPs in the KRT1 interval.

ABSTRACT: Efforts to develop effective therapeutic treatments for promoting fast wound healing after injury to the epidermis are hindered by a lack of understanding of the factors involved. Re-epithelialization is an essential step of wound healing involving the migration of epidermal keratinocytes over the wound site. Here, we examine genetic variants in the keratin-1 (KRT1) locus for association with migration rates of human epidermal keratinocytes (HEK) isolated from different individuals. Although the role of intermediate filament genes, including KRT1, in wound activated keratinocytes is well established, this is the first study to examine if genetic variants in humans contribute to differences in the migration rates of these cells. Using an in vitro scratch wound assay we observe quantifiable

SUBMITTER: Tao H 

PROVIDER: S-EPMC1933256 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature