Chick Hairy1 protein interacts with Sap18, a component of the Sin3/HDAC transcriptional repressor complex.

ABSTRACT:

Background

The vertebrate adult axial skeleton, trunk and limb skeletal muscles and dermis of the back all arise from early embryonic structures called somites. Somites are symmetrically positioned flanking the embryo axial structures (neural tube and notochord) and are periodically formed in a anterior-posterior direction from the presomitic mesoderm. The time required to form a somite pair is constant and species-specific. This extraordinary periodicity is proposed to depend on an underlying somitogenesis molecular clock, firstly evidenced by the cyclic expression of the chick hairy1 gene in the unsegmented presomitic mesoderm with a 90 min periodicity, corresponding to the time required to form a somite pair in the chick embryo. The number of hairy1 oscillations at any given mom

SUBMITTER: Sheeba CJ 

PROVIDER: S-EPMC1933423 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature