Towards the high-resolution protein structure prediction. Fast refinement of reduced models with all-atom force field.

ABSTRACT:

Background

Although experimental methods for determining protein structure are providing high resolution structures, they cannot keep the pace at which amino acid sequences are resolved on the scale of entire genomes. For a considerable fraction of proteins whose structures will not be determined experimentally, computational methods can provide valuable information. The value of structural models in biological research depends critically on their quality. Development of high-accuracy computational methods that reliably generate near-experimental quality structural models is an important, unsolved problem in the protein structure modeling.

Results

Large sets of structural decoys have been generated using reduced conformational space protein modeling tool CABS. Subsequently,

SUBMITTER: Kmiecik S 

PROVIDER: S-EPMC1933428 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature