Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms.

ABSTRACT:

Background

Abdominal aortic aneurysms are a common disorder with an incompletely understood etiology. We used Illumina and Affymetrix microarray platforms to generate global gene expression profiles for both aneurysmal (AAA) and non-aneurysmal abdominal aorta, and identified genes that were significantly differentially expressed between cases and controls.

Results

Affymetrix and Illumina arrays included 18,057 genes in common; 11,542 (64%) of these genes were considered to be expressed in either aneurysmal or normal abdominal aorta. There were 3,274 differentially expressed genes with a false discovery rate (FDR)

SUBMITTER: Lenk GM 

PROVIDER: S-EPMC1934369 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature