Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia.

ABSTRACT:

Background

Evidence of genetic association between the NRG1 (Neuregulin-1) gene and schizophrenia is now well-documented. Furthermore, several recent reports suggest association between schizophrenia and single-nucleotide polymorphisms (SNPs) in ERBB4, one of the receptors for Neuregulin-1. In this study, we have extended the previously published associations by investigating the involvement of all eight genes from the ERBB and NRG families for association with schizophrenia.

Methods

Eight genes from the ERBB and NRG families were tested for association to schizophrenia using a collection of 396 cases and 1,342 blood bank controls ascertained from Aberdeen, UK. A total of 365 SNPs were tested. Association testing of both alleles and genotypes was carried out using the fast F

SUBMITTER: Benzel I 

PROVIDER: S-EPMC1934910 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature