Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific.

ABSTRACT:

Background

In a mammalian host, the cell surface of African trypanosomes is protected by a monolayer of a single variant surface glycoprotein (VSG). The VSG is central to antigenic variation; one VSG gene is expressed at any one time and there is a low frequency stochastic switch to expression of a different VSG gene. The genome of Trypanosoma brucei contains a repertoire of > 1000 VSG sequences. The degree of conservation of the genomic VSG repertoire in different strains has not been investigated in detail.

Results

Eighteen expressed VSGs from Ugandan isolates were compared with homologues (> 40 % sequence identity) in the two available T. brucei genome sequences. Fourteen homologues were present in the genome of Trypanosoma brucei brucei TREU927 from Kenya and fourteen in

SUBMITTER: Hutchinson OC 

PROVIDER: S-EPMC1934917 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature