Gamma-Tubulin function during female germ-cell development and oogenesis in Drosophila.

ABSTRACT: A series of unconventional microtubule organizing centers play a fundamental role during egg chamber development in Drosophila. To gain a better understanding of their molecular nature, we have studied the centrosomal component gamma-tubulin during Drosophila oogenesis. We find that although single mutations in either of the two gamma-tubulin genes identified in Drosophila do not affect oogenesis progression the simultaneous depletion of both protein products has severe consequences. The combination of loss-of-function mutant alleles for the two gamma-tubulin genes leads to mitotic defects in female germ cells, resulting in agametic ovaries. A combination of weaker mutant alleles instead allows female germ-cell development to proceed, although the resulting egg chambers display pleiotropic

SUBMITTER: Tavosanis G 

PROVIDER: S-EPMC193549 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature