An additional role for the F-box motif: gene regulation within the Neurospora crassa sulfur control network.

ABSTRACT: The F-box represents a protein motif originally identified as a conserved amino-terminal domain within the Neurospora crassa negative regulator sulfur controller-2. Recently, F-boxes have been found within a number of cell cycle regulatory proteins, where they mediate ubiquitin-driven proteolytic events required for major cell cycle transitions. F-box function, however, is not restricted solely to cell cycle pathways. Here we present evidence expanding F-box function to encompass gene regulatory processes independent of the cell cycle through in vivo analysis of an F-box acting within the N. crassa sulfur regulatory network. The Neurospora sulfur circuit features a set of regulatory genes acting to modulate gene expression based on environmental sulfur conditions. These sulfur regulatory g

SUBMITTER: Kumar A 

PROVIDER: S-EPMC19360 | biostudies-literature | 1998 Mar

REPOSITORIES: biostudies-literature