Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice.

ABSTRACT:

Background

Tumor cells cultured in vitro are widely used to investigate the molecular biology of cancers and to evaluate responses to drugs and other agents. The full extent to which gene expression in cancer cells is modulated by extrinsic factors and by the microenvironment in which the cancer cells reside remains to be determined. Two cancer cell lines (A549 lung adenocarcinoma and U118 glioblastoma) were transplanted subcutaneously into immunodeficient mice to form tumors. Global gene-expression profiles of the tumors were determined, based on analysis of expression of human genes, and compared with expression profiles of the cell lines grown in culture.

Results

A bioinformatics approach associated genes that showed changes in their expression levels with functional clas

SUBMITTER: Creighton C 

PROVIDER: S-EPMC193633 | biostudies-literature | 2003

REPOSITORIES: biostudies-literature