Refinement of a chimpanzee pericentric inversion breakpoint to a segmental duplication cluster.

ABSTRACT:

Background

Pericentric inversions are the most common euchromatic chromosomal differences among humans and the great apes. The human and chimpanzee karyotype differs by nine such events, in addition to several constitutive heterochromatic increases and one chromosomal fusion event. Reproductive isolation and subsequent speciation are thought to be the potential result of pericentric inversions, as reproductive boundaries form as a result of hybrid sterility.

Results

Here we employed a comparative fluorescence in situ hybridization approach, using probes selected from a combination of physical mapping, genomic sequence, and segmental duplication analyses to narrow the breakpoint interval of a pericentric inversion in chimpanzee involving the orthologous human 15q11-q13 region

SUBMITTER: Locke DP 

PROVIDER: S-EPMC193642 | biostudies-literature | 2003

REPOSITORIES: biostudies-literature