An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR).

ABSTRACT:

Background

Diverse datasets, including genomic, transcriptomic, proteomic and metabolomic data, are becoming readily available for specific organisms. There is currently a need to integrate these datasets within an in silico modeling framework. Constraint-based models of Escherichia coli K-12 MG1655 have been developed and used to study the bacterium's metabolism and phenotypic behavior. The most comprehensive E. coli model to date (E. coli iJE660a GSM) accounts for 660 genes and includes 627 unique biochemical reactions.

Results

An expanded genome-scale metabolic model of E. coli (iJR904 GSM/GPR) has been reconstructed which includes 904 genes and 931 unique biochemical reactions. The reactions in the expanded model are both elementally and charge balanced. Network gap anal

SUBMITTER: Reed JL 

PROVIDER: S-EPMC193654 | biostudies-literature | 2003

REPOSITORIES: biostudies-literature