Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster.

ABSTRACT:

Background

Potassium channels are the largest and most diverse type of ion channel found in nature. The completion of the sequencing of the genomes of Drosophila melanogaster and Anopheles gambiae, which belong to the same order, the Diptera, allows us to compare and contrast K+-channel genes and gene families present within the genomes of two dipterans.

Results

This study identifies at least eight voltage-gated K+-channel genes in Anopheles, as well as three Slo-family, three Eag-family and six inward rectifier K+-channel genes. The genomic organization of K+-channel genes from Drosophila and Anopheles is well conserved. The sequence identity of the most similar K+-channel gene products between these two species ranges from 42% to 98%, with a mean value of 85%. Although mos

SUBMITTER: McCormack TJ 

PROVIDER: S-EPMC193658 | biostudies-literature | 2003

REPOSITORIES: biostudies-literature