Transmembrane movement of exogenous long-chain fatty acids: proteins, enzymes, and vectorial esterification.

ABSTRACT: The processes that govern the regulated transport of long-chain fatty acids across the plasma membrane are quite distinct compared to counterparts involved in the transport of hydrophilic solutes such as sugars and amino acids. These differences stem from the unique physical and chemical properties of long-chain fatty acids. To date, several distinct classes of proteins have been shown to participate in the transport of exogenous long-chain fatty acids across the membrane. More recent work is consistent with the hypothesis that in addition to the role played by proteins in this process, there is a diffusional component which must also be considered. Central to the development of this hypothesis are the appropriate experimental systems, which can be manipulated using the tools of molecular

SUBMITTER: Black PN 

PROVIDER: S-EPMC193871 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature