Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin.

ABSTRACT: When it was first proposed that the budding yeast Saccharomyces cerevisiae might serve as a model for human aging in 1959, the suggestion was met with considerable skepticism. Although yeast had proved a valuable model for understanding basic cellular processes in humans, it was difficult to accept that such a simple unicellular organism could provide information about human aging, one of the most complex of biological phenomena. While it is true that causes of aging are likely to be multifarious, there is a growing realization that all eukaryotes possess surprisingly conserved longevity pathways that govern the pace of aging. This realization has come, in part, from studies of S. cerevisiae, which has emerged as a highly informative and respected model for the study of life span regulatio

SUBMITTER: Bitterman KJ 

PROVIDER: S-EPMC193872 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature