Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators.

ABSTRACT:

Background

The Fox gene family comprises a large and functionally diverse group of forkhead-related transcriptional regulators, many of which are essential for metazoan embryogenesis and physiology. Defining conserved functional domains that mediate the transcriptional activity of Fox proteins will contribute to a comprehensive understanding of the biological function of Fox family genes.

Results

Systematic analysis of 458 protein sequences of the metazoan Fox family was performed to identify the presence of the engrailed homology-1 motif (eh1), a motif known to mediate physical interaction with transcriptional corepressors of the TLE/Groucho family. Greater than 50% of Fox proteins contain sequences with high similarity to the eh1 motif, including ten of the nineteen Fox su

SUBMITTER: Yaklichkin S 

PROVIDER: S-EPMC1939712 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature