Genome dynamics of short oligonucleotides: the example of bacterial DNA uptake enhancing sequences.

ABSTRACT: Among the many bacteria naturally competent for transformation by DNA uptake-a phenomenon with significant clinical and financial implications- Pasteurellaceae and Neisseriaceae species preferentially take up DNA containing specific short sequences. The genomic overrepresentation of these DNA uptake enhancing sequences (DUES) causes preferential uptake of conspecific DNA, but the function(s) behind this overrepresentation and its evolution are still a matter for discovery. Here I analyze DUES genome dynamics and evolution and test the validity of the results to other selectively constrained oligonucleotides. I use statistical methods and computer simulations to examine DUESs accumulation in Haemophilus influenzae and Neisseria gonorrhoeae genomes. I analyze DUESs sequence and nucleotide fr

SUBMITTER: Bakkali M 

PROVIDER: S-EPMC1939737 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature